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CLINICAL SYNTHESIS   |    
Prevention and Early Intervention: PTSD Following Traumatic Events
Suzanne C. Leaman, Ph.D.; Megan C. Kearns, Ph.D.; Barbara O. Rothbaum, Ph.D., ABPP
FOCUS 2013;11:321-327. doi:10.1176/appi.focus.11.3.321
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Author Information and CME Disclosure

Suzanne C. Leaman, Ph.D., Emory University School of Medicine

Megan C. Kearns, Ph.D., Emory University School of Medicine

Suzanne C. Leaman and Megan C. Kearns report no competing interests.

Barbara O. Rothbaum, Ph.D., ABPP, Emory University School of Medicine

Dr. Rothbaum reports the following disclosure: Co-owner, Virtually Better Inc.

Send correspondence to Barbara O. Rothbaum, Ph.D., ABPP, Emory University School of Medicine, 1256 Briarcliff Road, Atlanta, GA 30306; e-mail: brothba@emory.edu

Abstract

Posttraumatic stress disorder (PTSD) is often a chronic condition that has a significant impact on the individual and society. In attempts to prevent the disorder for those at risk, researchers have explored predictors of PTSD with limited success. As an alternative, early treatment options have been developed and are reviewed here, including pharmacological approaches and psychosocial interventions. While few early interventions or predictors have been shown to be consistently efficacious, recommendations are provided for future research building on recent promising findings in biomarkers, pharmacotherapy, and exposure-based psychotherapy interventions.

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Table 1.Proposed Matrix of Risk Domains and Measures of PTSD for Further Researcha
Table Footer Note

a Adapted from “Post-Traumatic Stress Disorder (PTSD) Risk Prediction,” National Institute of Mental Health, 2011 (http://www.nimh.nih.gov/research-funding/scientific-meetings/2011/post-traumatic-stress-disorder-ptsd-risk-prediction/index.shtml).

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Which medication has FDA approval for treatment of PTSD?

See Friedman: PTSD Pharmacotherapeutic Approaches, p 315–320
2.
Which anticonvulsant has shown promise for PTSD treatment?

See Friedman: Anticonvulsant/antikindling agents, p 317
3.
Which medication is recommended as an adjunctive treatment for partial responders to first-line treatments?

See Friedman: Antidepressants; Antiadrenergic Agents; Gabaergic Agonists; Atypical Antipsychotic Medications, p 316–318
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