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Chapter 16. Bipolar Disorder in Late Life

John L. Beyer, M.D.
DOI: 10.1176/appi.books.9781585623754.392470

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Bipolar disorder can be a severe, relapsing mental illness, and it shares characteristics with both major depressive disorder and schizophrenia. Like depressive disorders, bipolar disorder features recurrent episodes of altered mood that interfere with cognition and functioning. Like schizophrenia, it is a chronic disorder that often contains psychotic episodes and similar pathological findings. However, in contrast to late-life depression and schizophrenia, information about late-life bipolar disorder is relatively scarce (Bauer et al. 2002; Charney et al. 2003; Depp et al. 2005; Unutzer and Bruce 2002). Even basic facts, such as how age may affect the development or expression of bipolar disorder, where older adults with bipolar disorder live or access their health care, or how late-life bipolar disorder may affect social support, have been relatively lightly studied. Further, answers to elementary questions regarding such issues as the prevalence of late-life bipolar disorder and the best treatment practices are unclear (Charney et al. 2003; Unutzer and Bruce 2002).

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Young RC, Jain H, Kiosses DN, et al: Antidepressant-associated mania in late life. Int J Geriatr Psychiatry 18:421–424, 2003
[PubMed]
 
Young RC, Gyulai L, Mulsant BH, et al: Pharmacotherapy of bipolar disorder in old age: review and recommendations. Am J Geriatr Psychiatry 12:342–357, 2004
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Zis AP, Grof P, Goodwin FK: The natural course of affective disorders: implications for lithium prophylaxis, in Lithium: Controversies and Unsolved Issues. Edited by Cooper TB, Gershon S, Kline NS, Shou M. Amsterdam, The Netherlands, Excerpta Medica, 1979, pp 381–398
 
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Sample questions:
1.
The exact prevalence of bipolar disorder in late life is uncertain, but several large studies have reported prevalence rates in community samples to be
2.
Which of the following variables is decreased or lower in older patients with bipolar disorder as compared with younger patients with bipolar disorder?
3.
Evaluation of patients with late-life bipolar disorder reveals various patterns of presentation. Which of the following patterns is the most frequent in elderly patients with bipolar disorder?
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Related Content
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The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 37.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 23.  >
The American Psychiatric Publishing Textbook of Geriatric Psychiatry, 4th Edition > Chapter 3.  >
The American Psychiatric Publishing Textbook of Geriatric Psychiatry, 4th Edition > Chapter 7.  >
The American Psychiatric Publishing Textbook of Geriatric Psychiatry, 4th Edition > Chapter 9.  >
Topic Collections
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PubMed Articles
Antidepressants for bipolar disorder: A meta-analysis of randomized, double-blind, controlled trials. Neural Regen Res 2013;8(31):2962-74.doi:10.3969/j.issn.1673-5374.2013.31.009.
 
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