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Chapter 6. Animal Models

David M. Lyons, Ph.D.
DOI: 10.1176/appi.books.9781585623860.408558

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Practical limitations and ethical concerns restrict opportunities for randomized, controlled trials of potentially new drug treatments for human psychiatric disorders. Prospects for discovering the neural mechanisms of action of established therapeutic drugs are also less prevalent in psychiatry than other fields of medicine, because biopsies of diseased brain tissue in humans are seldom performed. Animal models are therefore essential for screening new drugs and for understanding how drug therapies in humans restore the neural basis of mental health. This chapter addresses the validity, utility, and limitations of animal models in psychopharmacological research.

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FIGURE 6–1. Psychiatric endophenotypes mediate the link between causal risk factors and the resulting psychiatric disorders defined in DSM-IV-TR.Representative examples and nonexhaustive lists of risk factors, endophenotypes, and disorders are provided to illustrate this theoretical framework for psychiatry neuroscience and psychopharmacological research.

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Which of the following terms refers to the theoretical rationale for linking a psychotropic disorder to an endpoint measured in the animal model?
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Classic learned helplessness animal models have a high degree of validity as a model for depression in all of the following areas except
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Which of the following is a major limitation of chronic stress models in rodents?
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