Sections
Fluvoxamine: Introduction | Structure–Activity Relations | Mechanism of Action | Pharmacological Profile | Pharmacokinetics and Disposition | Indications and Efficacy | Side Effects and Toxicology | Drug–Drug Interactions | Pregnancy and Lactation | Conclusion | References
Excerpt
Fluvoxamine is a member of the selective serotonin
reuptake inhibitor (SSRI) family of drugs. Initially manufactured
by Duphar Laboratories in the United Kingdom in 1971, fluvoxamine
was registered as an antidepressant in Switzerland in 1983, becoming
the first drug in the now hugely popular SSRI class to reach the
market (Freeman 1991). Since its introduction, fluvoxamine
has undergone a wide range of trials to assess its therapeutic potential
in depression and across several anxiety disorders, including obsessive-compulsive
disorder (OCD). Fluvoxamine has been available in the United States
since 1994, when it received U.S. Food and Drug Administration (FDA)
approval for the treatment of OCD (Ware 1997). More
than 28 million people worldwide have been treated with fluvoxamine
(Buchberger and Wagner 2002).