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Chapter 51. Neurobiology of Personality Disorders

Royce Lee, M.D.; Emil F. Coccaro, M.D.
DOI: 10.1176/appi.books.9781585623860.433298

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The personality disorders as represented in the DSM-IV-TR (American Psychiatric Association 2000) and ICD-10 (World Health Organization 1992) classification systems are characterized by trait-like disturbances in emotion, cognition, and social function. As a group, they share the important commonalities of chronic course with early onset, relative preservation of intelligence, and absence of gross neurological deficit. In order to summarize the neurobiological literature, we have chosen a heuristic organization that emphasizes the location of "lesion" of personality disorder within neural networks mediating mental activity. This is opposed to a model that locates the lesion in personality, phenomenology (Siever and Davis 1991), or molecules. All of these are equally valid as heuristics. The advantage of this approach is that it allows a novel, useful reorganization of the existing database, characterized by a close relationship between the identified neurobiological abnormalities and a neurobiologically plausible brain-based model.

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CME Activity

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Sample questions:
1.
The process whereby information regarding the environment is represented in symbolic form by electrophysiological activity in biological neural networks is known as
2.
Which of the following electrophysiological or structural changes has been reported in patients with schizotypal personality disorder?
3.
Which of the following are examples of metarepresentational abnormalities?
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Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 55.  >
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The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 47.  >
Topic Collections
Psychiatric News
PubMed Articles
Depression in patients with borderline personality disorder. Harv Rev Psychiatry 2014 Sep-Oct;22(5):266-73.doi:10.1097/HRP.0000000000000045.
Display of individuality in avoidance behavior and risk assessment of inbred mice. Front Behav Neurosci 2014;8():314.doi:10.3389/fnbeh.2014.00314.
 
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