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Chapter 16. Posttraumatic Epilepsy

Daniel J. Luciano, M.D.; Kenneth Alper, M.D.; Siddhartha Nadkarni, M.D.
DOI: 10.1176/appi.books.9781585624201.678420

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Excerpt

Recovery from a traumatic brain injury (TBI) involves dealing with problems that can be physical, cognitive, and psychological in nature. The development of posttraumatic epilepsy further complicates recovery by means of the physical and psychological consequences of seizures as well as the medications used for their treatment. Whereas most posttraumatic symptoms show gradual improvement of variable degree over time, epilepsy is unique in recurring suddenly and unexpectedly, leading to a physical and psychological setback that can negatively affect recovery and that has been shown to worsen functional outcome after TBI (Asikainen et al. 1998).

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Table Reference Number
Table 16–1. Partial seizure manifestations
Table Reference Number
Table 16–2. Psychic phenomena during partial seizures
Table Reference Number
Table 16–3. Beneficial and harmful psychotropic effects of antiepileptic drugs

References

Agrawal A, Timothy J, Pandit L, et al: Post-traumatic epilepsy: an overview. Clin Neurol Neurosurg 108:433–439, 2006
[PubMed]
 
Aldenkamp AP, Baker G: A systematic review of the effects of lamotrigine on cognitive function and quality of life. Epilepsy Behav 2:85–91, 2001
[PubMed]
 
Alper K, Devinsky O, Perrine K, et al: Nonepileptic seizures and childhood sexual and physical abuse. Neurology 43:1950–1953, 1993
[PubMed]
 
Alper K, Devinsky O, Perrine K, et al: Psychiatric classification of nonconversion nonepileptic seizures. Arch Neurol 52:199–201, 1995
[PubMed]
 
Alper KR, Barry JJ, Balabanov AJ: Treatment of psychosis, aggression, and irritability in patients with epilepsy. Epilepsy Behav 3:13–18, 2002
[PubMed]
 
Alper K, Schwartz KA, Kolts RL, et al: Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) Summary Basis of Approval Reports. Biol Psychiatry 62:345–354, 2007
[PubMed]
 
Alper K, Kuzniecky R, Carlson C, et al: Postictal psychosis in partial epilepsy: a case-control study. Ann Neurol 63:602–610, 2008
[PubMed]
 
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision. Washington, DC, American Psychiatric Association, 2000
 
Andersohn F, Schade R, Willich SN, et al: Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior. Neurology 75:335–340, 2010
[PubMed]
 
Angeleri F, Majkowski J, Cacchio G, et al: Posttraumatic epilepsy risk factors: one year prospective study after head injury. Epilepsia 40:1222–1230, 1999
[PubMed]
 
Annegers JF, Hauser WA, Coan SP, et al: A population-based study of seizures after traumatic brain injuries. N Engl J Med 338:20–24, 1998
[PubMed]
 
Arif H, Buchsbaum R, Weintraub D, et al: Patient-reported cognitive side effects of antiepileptic drugs: predictors and comparison of all commonly used antiepileptic drugs. Epilepsy Behav 14:202–209, 2009
[PubMed]
 
Asikainen I, Kaste M, Sarna S: Early and late posttraumatic seizures in traumatic brain injury rehabilitation patients: brain injury factors causing late seizures and influence of seizures on long-term outcome. Epilepsia 40:584–589, 1998
 
Bauer G, Trinka E: Nonconvulsive status epilepticus and coma. Epilepsia 51:177–190, 2009
[PubMed]
 
Binnie CD, Kasteleijn-Nolst DG, Smit AM, et al: Interactions of epileptiform EEG discharges and cognition. Epilepsy Res 1:239–245, 1987
[PubMed]
 
Chang BS, Lowenstein DH: Practice parameter: antiepileptic drug prophylaxis in severe traumatic brain injury: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 60:10–16, 2003
[PubMed]
 
Christensen J, Vestergaard M, Mortensen PB, et al: Epilepsy and risk of suicide: a population-based case-control study. Lancet Neurol 6:693–698, 2007
[PubMed]
 
Christensen J, Pedersen MG, Perdersen CB, et al: Long-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort study. Lancet 373:1105–1110, 2009
[PubMed]
 
Da Silva AM, Nunes B, Vaz AR, et al: Posttraumatic epilepsy in civilians: clinical and electroencephalographic studies. Acta Neurochir Suppl 55:56–63, 1992
 
Desai B, Whitman S, Bouffard DA: The role of the EEG in epilepsy of long duration. Epilepsia 29:601–606, 1988
[PubMed]
 
Diaz-Arrastia R, Agostini MA, Madden CJ, et al: Posttraumatic epilepsy: the endophenotypes of a human model of epileptogenesis. Epilepsia 50 (suppl 2):14–20, 2009
 
Dikmen SS, Temkin NR, Miller B, et al: Neurobehavioral effects of phenytoin prophylaxis of posttraumatic seizures. JAMA 265:1271–1277, 1991
[PubMed]
 
Drislane F: Presentation, evaluation, and treatment of nonconvulsive status epilepticus. Epilepsy Behav 1:301–314, 2000
[PubMed]
 
Ferguson PL, Smith GM, Wannamaker BB, et al: A population-based study of risk of epilepsy after hospitalization for traumatic brain injury. Epilepsia 51:891–898, 2010
[PubMed]
 
First MB, Spitzer RL, Gibbon M, et al: Structured Clinical Interview for DSM-IV Axis I Disorders. Washington, DC, American Psychiatric Association, 1997
 
Fromm GH, Wessel HB, Glass JD, et al: Imipramine in absence and myoclonic-astatic seizures. Neurology 28:953–957, 1978
[PubMed]
 
Gilliam FG, Barry JJ, Hermann BP, et al: Rapid detection of major depression in epilepsy: a multicentre study. Lancet Neurol 5:399–405, 2006
[PubMed]
 
Gupta RK, Saksena S, Agrawal A, et al: Diffusion tensor imaging in late posttraumatic epilepsy. Epilepsia 46:1465–1471, 2005
[PubMed]
 
Hahn YS, Fuchs S, Flannery AM, et al: Factors influencing posttraumatic seizures in children. Neurosurgery 22:864–867, 1988
[PubMed]
 
Haltiner AM, Temkin NR, Dikmen SS: Risk of seizure recurrence after the first late posttraumatic seizure. Arch Phys Med Rehabil 78:835–840, 1997
[PubMed]
 
Hauser WA, Hesdorffer DC: Epilepsy: Frequency, Causes and Consequences. New York, Demos, 1990
 
Hesdorffer DC, Kanner AM: The FDA alert on suicidality and antiepileptic drugs: fire or false alarm? Epilepsia 50:978–986, 2009
[PubMed]
 
Hesdorffer DC, Hauser WA, Olafsson E, et al: Depression and suicide attempt as risk factors for incident unprovoked seizures. Ann Neurol 59:35–41, 2006
[PubMed]
 
Jabbari B, Vengrow MI, Salazar AM, et al: Clinical and radiological correlates of EEG in the late phase of head injury: a study of 515 Vietnam veterans. Electroencephalogr Clin Neurophysiol 64:285–293, 1986
[PubMed]
 
Jefferson JW, Pradko JF, Muir KT: Bupropion for major depressive disorder: pharmacokinetic and formulation considerations. Clin Ther 27:1685–1695, 2005
[PubMed]
 
Jennett B: Epilepsy After Non-Missile Head Injuries. Chicago, IL, Year Book Medical, 1975
 
Jennett B, Van De Sande J: EEG prediction of post-traumatic epilepsy. Epilepsia 16:251–256, 1975
[PubMed]
 
Johnson EK, Jones JE, Seidenberg M, et al: The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy. Epilepsia 45:544–550, 2004
[PubMed]
 
Jones KE, Puccio AM, Harshman KJ, et al: Levetiracetam versus phenytoin for seizure prophylaxis in severe traumatic brain injury. Neurosurg Focus 25:E3, 2008
 
Kanner AM, Ostrovskaya A: Long-term significance of postictal psychotic episodes, II: are they predictive of interictal psychotic episodes? Epilepsy Behav 12:154–156, 2008
[PubMed]
 
Kanner AM, Stagno S, Kotagal P, et al: Postictal psychiatric events during prolonged video-electroencephalographic monitoring studies. Arch Neurol 53:258–263, 1996
[PubMed]
 
Kazibutowska Z, Stelmach-Wawrzyczek M, Majchrzak R: Results of prospective 24-hour EEG studies of patients after cranio-cerebral injuries. Neurol Neurochir Pol 26:304–310, 1992
[PubMed]
 
Kollevold T: Immediate and early seizures after head injuries: part III. J Oslo City Hosp 28:77–86, 1978
[PubMed]
 
Kotsopoulos I, de Krom M, Kessels F, et al: Incidence of epilepsy and predictive factors of epileptic and non-epileptic seizures. Seizure 14:175–182, 2005
[PubMed]
 
Kumar R, Gupta RK, Husain M, et al: Magnetization transfer MR imaging in patients with posttraumatic epilepsy. Am J Neuroradiol 23:218–224, 2003
 
Levy M, Berson A, Cook T, et al: Treatment of agitation following traumatic brain injury: a review of the literature. NeuroRehabilitation 20:279–306, 2005
[PubMed]
 
Logsdail SJ, Toone BK: Post-ictal psychoses: a clinical and phenomenological description. Br J Psychiatry 152:246–252, 1988
[PubMed]
 
Luat AF, Asano E, Rothermel R, et al: Psychosis as a manifestation of frontal lobe epilepsy. Epilepsy Behav 12:200–204, 2008
[PubMed]
 
Luciano D: Partial seizures of frontal and temporal origin, in Neurologic Clinics, Epilepsy I: Diagnosis and Treatment. Oxford, UK, Elsevier, 1993, pp 805–822
 
Luciano D, Alper K: Psychiatric aspects of seizures and epilepsy, in Psychiatric Care of the Medical Patient. Edited by Stoudemire A, Fogel BS, Greenberg DB. Oxford, UK, Oxford University Press, 2000, pp 635–651
 
McCrory PR, Berkovic SF: Concussive convulsions: incidence in sport and treatment recommendations. Sports Med 25:131–136, 1998
[PubMed]
 
Nadkarni S: Pitfalls in diagnosing epilepsy: a case report. Epilepsia 47 (suppl 1):6–8, 2006
 
Pagni CA, Zenga F: Posttraumatic epilepsy with special emphasis on prophylaxis and prevention. Acta Neurochir Suppl 93:27–34, 2005
[PubMed]
 
Perucca E: Clinically relevant drug interactions with antiepileptic drugs. Br J Clin Pharmacol 61:246- 255, 2006
 
Pollock BG, Sweet RA, Kirshner M, et al: Bupropion plasma levels and CYP2D6 phenotype. Ther Drug Monit 18:581–585, 1996
[PubMed]
 
Pompili M, Girardi P, Tatarelli R: Death from suicide versus mortality from epilepsy in the epilepsies: a meta-analysis. Epilepsy Behav 9:641–648, 2006
[PubMed]
 
Preskorn SH, Fast GA: Tricyclic antidepressant-induced seizures and plasma drug concentration. J Clin Psychiatry 53:160–162, 1992
[PubMed]
 
Profitlich T, Hoppe C, Reuber M, et al: Ictal neuropsychological findings in focal nonconvulsive status epilepticus. Epilepsy Behav 12:269–275, 2008
[PubMed]
 
Raymont V, Salazar AM, Lipsky R, et al: Correlates of posttraumatic epilepsy 35 years following combat brain injury. Neurology 75:224–229, 2010
[PubMed]
 
Resor SR, Resor LD: Use of sustained-release bupropion in patients with epilepsy. Epilepsia 44 (suppl 9):111, 2003
 
Riggio S: Psychiatric manifestations of nonconvulsive status epilepticus. Mt Sinai J Med 73:960–966, 2006
[PubMed]
 
Salazar AM, Jabbari B, Vance SC, et al: Epilepsy after penetrating head injury, 1: clinical correlates. A report of the Vietnam Head Injury Study. Neurology 35:1406–1414, 1985
[PubMed]
 
Sarah O: Review of the role of anticonvulsant prophylaxis following brain injury. J Clin Neurosci 11:1–3, 2004
 
Sengoku A, Toichi M, Murai T: Dreamy states and psychoses in temporal lobe epilepsy: mediating role of affect. Psychiatry Clin Neurosci 51:23–26, 1997
[PubMed]
 
Sharpe D, Faye C: Non-epileptic seizures and child sexual abuse: a critical review of the literature. Clin Psychol Rev 26:1020–1040, 2006
[PubMed]
 
Sherer M, Yablon SA, Nakase-Richardson R: Patterns of recovery of posttraumatic confusional state in neurorehabilitation admissions after traumatic brain injury. Arch Phys Med Rehabil 90:1749–1754, 2009
[PubMed]
 
Showalter PE, Kimmel DN: Stimulating consciousness and cognition following severe brain injury: a new potential clinical use for lamotrigine. Brain Inj 14:997–1001, 2000
[PubMed]
 
Silver JM, McAllister TW, Arciniegas DB: Depression and cognitive complaints following mild traumatic brain injury. Am J Psychiatry 166:653–661, 2009
[PubMed]
 
Silverstone PH, Williams R, McMahon L, et al: Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice. Ann Gen Psychiatry 27:19, 2008
 
Tarulli A, Devinsky O, Alper K: Progression of postictal to interictal psychosis. Epilepsia 42:1468–1471, 2001
[PubMed]
 
Temkin NR: Risk factors for posttraumatic seizures in adults. Epilepsia 44 (suppl 10):18–20, 2003
 
Temkin NR: Preventing and treating posttraumatic seizures: the human experience. Epilepsia 50:10–13, 2009
[PubMed]
 
Temkin NR, Anderson GD, Winn HR, et al: Magnesium sulfate for neuroprotection after traumatic brain injury: a randomized controlled trial. Lancet Neurol 6:29–38, 2007
[PubMed]
 
Thapar A, Kerr M, Harold G: Stress, anxiety, depression, and epilepsy: investigating the relationship between psychological factors and seizures. Epilepsy Behav 14:134–140, 2009
[PubMed]
 
Torres AR, Whitney J, Gonzalez-Heydrich J: Attention-deficit/-hyperactivity disorder in pediatric patients with epilepsy: review of pharmacological treatment. Epilepsy Behav 12:217–233, 2008
[PubMed]
 
Tucker GJ: Seizures, in Textbook of Traumatic Brain Injury. Edited by Silver JM, McAllister TW, Yudofsky SC. Washington, DC, American Psychiatric Publishing, 2005, pp 309–318
 
Vespa PM, Nuwer MR, Nenov V, et al: Increased incidence and impact of nonconvulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring. J Neurosurg 91:750–760, 1999
[PubMed]
 
Walker AE, Erculei F: Post-traumatic epilepsy 15 years later. Epilepsia 11:17–26, 1970
[PubMed]
 
Watson NF, Barber JK, Doherty MJ, et al: Does glucocorticoid administration prevent late seizures after head injury? Epilepsia 45:690–694, 2004
[PubMed]
 
Weintraub D, Buchsbaum R, Resor SR, et al: Psychiatric and behavioral side effects of the newer antiepileptic drugs in adults with epilepsy. Epilepsy Behav 10:105–110, 2007
[PubMed]
 
Westbrook LE, Devinsky O, Geocadin R: Nonepileptic seizures after head injury. Epilepsia 39:978–982, 1998
[PubMed]
 
Willmore LJ: Posttraumatic epilepsy, in The Treatment of Epilepsy: Principles and Practice, 2nd Edition. Edited by Wyllie E. Baltimore, MD, Williams & Wilkins, 1996, pp 629–635
 
Wroblewski BA, McColgan K, Smith K, et al: The incidence of seizures during tricyclic antidepressant drug treatment in a brain-injured population. J Clin Psychopharmacol 10:124–128, 1990
[PubMed]
 
Wroblewski BA, Leary JM, Phelan AM, et al: Methylphenidate and seizure frequency in brain injured patients with seizure disorders. J Clin Psychiatry 53:86–89, 1992
[PubMed]
 
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