Editors

Alan F. Schatzberg, M.D.
Kenneth T. Norris Jr. Professor and Chair, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

Charles B. Nemeroff, M.D., Ph.D.
Reunette W. Harris Professor, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia

Contributors

Elias Aboujaoude, M.D.
Assistant Clinical Professor, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

W. Stewart Agras, M.D.
Professor of Psychiatry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

Jonathan M. Amiel, M.D.
Resident in Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York

Josephine Astrid Archer, B.Sc.
Research Student, Centre for Psychiatry, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, London, United Kingdom

Steven E. Arnold, M.D.
Professor and Director, Cellular and Molecular Neuropathology Program, Geriatric Psychiatry Section, Department of Psychiatry, Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania

Christos A. Ballas, M.D.
Assistant Professor of Clinical Psychiatry, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Jacob S. Ballon, M.D.
Chief Resident, Department of Psychiatry and Behavioral Science, Stanford University, Stanford, California

Matthew J. Bair, M.D., M.S.
Assistant Professor of Medicine, Division of General Internal Medicine and Geriatrics, Department of Medicine, Indiana University School of Medicine; Research Scientist, Regenstrief Institute, Inc.; and Center for Implementing Evidence-Based Practice, Richard Roudebush VA Medical Center, Indianapolis, Indiana

Gregory S. Berns, M.D., Ph.D.
Professor, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

Elisabeth B. Binder, M.D., Ph.D.
Assistant Professor, Department of Psychiatry and Behavioral Sciences and Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia; Head, RG Molecular Genetics of Depression, Max Planck Institute of Psychiatry, Munich, Germany

Pierre Blier, M.D., Ph.D.
Professor, Departments of Psychiatry and Cellular/Molecular Medicine, University of Ottawa; Research Director, Mood Disorders Research Unit, University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada

David R. Block, M.D.
Staff Psychiatrist, Student Health Services, San Francisco State University, San Francisco, California

Charles L. Bowden, M.D.
Clinical Professor of Psychiatry and Psychopharmacology, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas

Catherine Bresee, M.S.
Senior Research Associate, Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, California

Frank W. Brown, M.D.
Associate Professor of Psychiatry and Behavioral Sciences, Emory University School of Medicine, and Chief Medical Officer, Wesley Woods Geriatric Hospital, Emory Health-Care, Atlanta, Georgia

Mary F. Brunette, M.D.
Associate Professor of Psychiatry, Department of Psychiatry, Dartmouth Psychiatric Research Center, Dartmouth Medical School, Hanover, New Hampshire

Peter F. Buckley, M.D.
Professor and Chairman, Department of Psychiatry, and Associate Dean for Leadership Development, Medical College of Georgia, Augusta, Georgia

Joseph R. Calabrese, M.D.
Director, Center for Bipolar Disorder at Case Western Reserve University and University Hospitals Case Medical Center; Professor of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio

Carla M. Canuso, M.D.
Senior Director, Clinical Development, Ortho-McNeil Janssen Scientific Affairs, LLC, Titusville, New Jersey

Linda L. Carpenter, M.D.
Associate Professor, Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island

Dennis S. Charney, M.D.
Dean and Executive Vice President of Academic Affairs, Mount Sinai School of Medicine, New York, New York

Anita H. Clayton, M.D.
David C. Wilson Professor, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia School of Medicine, Charlottesville, Virginia

Emil F. Coccaro, M.D.
Professor and Chair of Psychiatry, Department of Psychiatry, University of Chicago, Chicago, Illinois

Kathryn M. Connor, M.D., M.H.S.
Associate Director of Clinical Research, Clinical Neuroscience and Ophthalmology, Merck & Co, Inc., North Wales, Pennsylvania (formerly Associate Professor, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina)

Monica Kelly Cowles, M.D., M.S.
Assistant Professor, Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute (WCI), Emory School of Medicine, Atlanta, Georgia

Joseph F. Cubells, M.D., Ph.D.
Associate Professor, Department of Psychiatry and Behavioral Sciences and Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia

Charles A. Dackis, M.D.
Associate Professor, Department of Psychiatry, and Medical Director of Clinical Services, Presbyterian Medical Center, University of Pennsylvania, Philadelphia, Pennsylvania

Jonathan R. T. Davidson, M.D.
Professor, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina

Albert A. Davis, B.S.
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia

Karon Dawkins, M.D.
Associate Professor of Psychiatry and Director of General Psychiatry Residency Training, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

William C. Dement, M.D., Ph.D.
Lowell W. and Josephine Q. Berry Professor, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California; Director, Stanford Sleep Disorders Center, Palo Alto, California

D. P. Devanand, M.D.
Professor of Clinical Psychiatry and Neurology, College of Physicians and Surgeons, Columbia University; Co-Director, Memory Disorders Center, New York State Psychiatric Institute, New York, New York

C. Lindsay DeVane, Pharm.D.
Professor of Psychiatry and Behavioral Sciences and Director, Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina

David F. Dinges, Ph.D.
Professor of Psychology in Psychiatry, Chief, Division of Sleep and Chronobiology, Director, Unit for Experimental Psychiatry, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Barbara D'Orio, M.D., M.P.A.
Associate Professor, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

David L. Dunner, M.D.
Professor, Department of Psychiatry and Behavioral Sciences, and Director, Center for Anxiety and Depression, University of Washington, Seattle, Washington

Clifford J. Ehmke, M.D.
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

Dwight L. Evans, M.D.
Ruth Meltzer Professor and Chairman, Professor of Psychiatry, Medicine, and Neuroscience, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Elise M. Fallucco, M.D.
Clinical Fellow—Child and Adolescent Psychiatry, Washington University School of Medicine, St. Louis, Missouri

Susana V. Fernandez, B.A.
Research Interviewer, Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia

Adriana E. Foster, M.D.
Assistant Professor, Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia

Marlene P. Freeman, M.D.
Center for Women's Mental Health, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School

Mark A. Frye, M.D.
Consultant, Department of Psychiatry and Psychology, Director, Mayo Mood Clinic and Research Program, Mayo Clinic, Rochester, Minnesota

Keming Gao, M.D., Ph.D.
Director, Mood and Anxiety Clinic, Assistant Professor of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio

Amir Garakani, M.D.
Visiting Associate, Mount Sinai School of Medicine, New York, New York

Steven J. Garlow, M.D., Ph.D.
Director of Adult Mental Health Services and Emergency Psychiatry, Emory University Hospital; Assistant Professor, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

Alan J. Gelenberg, M.D.
President and CEO, Healthcare Technology Systems Inc., Madison, Wisconsin; Clinical Professor of Psychiatry, University of Wisconsin, Madison, Wisconsin; Professor Emeritus of Psychiatry, University of Arizona College of Medicine, Tucson, Arizona

Charles F. Gillespie, M.D., Ph.D.
Assistant Professor, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

Elizabeth H. Gillespie, D.O.
Child and Adolescent Psychiatry Fellow, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia

Donald C. Goff, M.D.
Director, Schizophrenia Program, Massachusetts General Hospital; Associate Professor of Psychiatry, Harvard Medical School, Boston, Massachusetts

Robert N. Golden, M.D.
Professor of Psychiatry and Dean, School of Medicine and Public Health, University of Wisconsin–Madison, Madison, Wisconsin

Jennifer Gotto, M.D.
Chief, Department of Psychiatry, Division of Supportive Care Medicine, City of Hope Cancer Center, Duarte, California

Todd D. Gould, M.D.
Assistant Professor, Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, Maryland

Anthony A. Grace, Ph.D.
Professor of Neuroscience, Psychiatry, and Psychology, Department of Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Alan I. Green, M.D.
Raymond Sobel Professor of Psychiatry and Chairman, Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire

Raquel E. Gur, M.D., Ph.D.
Professor and Director, Schizophrenia Research Center, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania

Ebrahim Haroon, M.D.
Assistant Professor, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

Christine M. Heim, Ph.D.
Assistant Professor, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

Eric Hollander, M.D.
Professor of Psychiatry and Director of Clinical Psychopharmacology, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York

Florian Holsboer, M.D., Ph.D.
Director and Professor, Max Planck Institute of Psychiatry, Munich, Germany

Jinger G. Hoop, M.D., M.F.A.
Assistant Professor, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin

Sandra Juric, B.A.
Research Interviewer, Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia

Ned H. Kalin, M.D.
Hedberg Professor and Chair, Department of Psychiatry; and Director, HealthEmotions Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin

Walter H. Kaye, M.D.
Professor of Psychiatry and Director of the Eating Disorder Program, Department of Psychiatry, University of California at San Diego, La Jolla, California

Paul E. Keck Jr., M.D.
President–CEO, Lindner Center of HOPE, Mason, Ohio; Lindner Professor of Psychiatry and Neuroscience and Executive Vice Chair, University of Cincinnati College of Medicine, Cincinnati, Ohio

David E. Kemp, M.D.
Director, Mood and Metabolic Clinic, Assistant Professor of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio

Ashley P. Kennedy, B.S.
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

Terence A. Ketter, M.D.
Professor of Psychiatry and Behavioral Sciences and Chief, Bipolar Disorders Clinic, Stanford University School of Medicine, Stanford, California

Clinton D. Kilts, Ph.D.
Paul Janssen Professor and Vice Chair for Research, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

Lorrin M. Koran, M.D.
Professor, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

Ania Korszun, Ph.D., M.D., M.R.C.Psych.
Professor of Psychiatry, Centre for Psychiatry, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, London, United Kingdom

Helena C. Kraemer, Ph.D.
Professor of Biostatistics in Psychiatry, Emerita, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

Erin E. Krebs, M.D., M.P.H.
Assistant Professor of Medicine, Division of General Internal Medicine and Geriatrics, Department of Medicine, Indiana University School of Medicine; Research Scientist, Regenstrief Institute, Inc.; and Center for Implementing Evidence-Based Practice, Richard Roudebush VA Medical Center, Indianapolis, Indiana

K. Ranga Rama Krishnan, M.D.
Professor and Chairman, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina; Dean, Duke–NUS Graduate Medical School Singapore

Kurt Kroenke, M.D.
Professor of Medicine, Division of General Internal Medicine and Geriatrics, Department of Medicine, Indiana University School of Medicine; Research Scientist, Regenstrief Institute, Inc.; and Center for Implementing Evidence-Based Practice, Richard Roudebush VA Medical Center, Indianapolis, Indiana

David J. Kupfer, M.D.
Thomas Detre Professor and Chair, Department of Psychiatry, and Professor of Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

James J. Lah, M.D., Ph.D.
Associate Professor, Department of Neurology, Emory University School of Medicine, Atlanta, Georgia

Joseph B. Layde, M.D., J.D.
Professor, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin

Royce Lee, M.D.
Assistant Professor of Psychiatry, Department of Psychiatry, University of Chicago, Chicago, Illinois

Allan I. Levey, M.D., Ph.D.
Professor and Chair, Department of Neurology, Emory University School of Medicine, Atlanta, Georgia

David A. Lewis, M.D.
UPMC Professor, Translational Neuroscience Program, Departments of Psychiatry and Neuroscience; Director, Center for the Neuroscience of Mental Disorders; and Associate Director for Basic Research, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Jeffrey A. Lieberman, M.D.
Chairman, Department of Psychiatry, College of Physicians and Surgeons, Columbia University; Director, New York State Psychiatric Institute; Director, Lieber Center for Schizophrenia Research; Psychiatrist-in-Chief, New York Presbyterian Hospital and Columbia University Medical Center, New York, New York

David M. Lyons, Ph.D.
Associate Professor, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

Robert C. Malenka, M.D., Ph.D.
Pritzker Professor of Psychiatry and Behavioral Sciences, Stanford Brain Research Institute, Stanford University School of Medicine, Stanford, California

Husseini K. Manji, M.D.
Vice President, CNS and Pain, Johnson & Johnson Pharmaceutical Research & Development, Titusville, New Jersey

Stephen R. Marder, M.D.
Professor and Director, Section on Psychosis, Semel Institute of Neuroscience and Human Behavior, University of California at Los Angeles; Director, Desert Pacific Mental Illness Research, Education, and Clinical Center, West Los Angeles Veterans Administration Medical Center, Los Angeles, California

Sanjay J. Mathew, M.D.
Director, Mood and Anxiety Disorders Program, and Associate Professor of Psychiatry, Mount Sinai School of Medicine, New York, New York

Helen S. Mayberg, M.D.
Professor, Department of Psychiatry and Behavioral Sciences, and Professor, Department of Neurology, Emory University School of Medicine, Atlanta, Georgia

W. Vaughn McCall, M.D., M.S.
Professor and Chair, Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine; Medical Director, Sleep Center, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina

William M. McDonald, M.D.
Professor of Psychiatry and J.B. Fuqua Chair for Late-Life Depression, Emory University School of Medicine; Chief, Division of Geriatric Psychiatry, Director, Fuqua Center for Late-Life Depression, Atlanta, Georgia

Susan L. McElroy, M.D.
Chief Research Officer, Lindner Center of HOPE, Mason, Ohio; Professor of Psychiatry and Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio

Thomas W. Meeks, M.D.
Assistant Professor of Psychiatry, Division of Geriatric Psychiatry, University of California–San Diego, VA San Diego Healthcare System, San Diego, California

Darlene S. Melchitzky, M.S.
Research Principal, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Laboratory Director, Department of Biology, Mercyhurst College, Erie, Pennsylvania

Emmanuel Mignot, M.D., Ph.D.
Howard Hughes Medical Institute Investigator; Professor of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California; Director, Center for Narcolepsy, Stanford Sleep Research Center, Palo Alto, California

Andrew H. Miller, M.D.
Professor, Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute (WCI), Emory School of Medicine, Atlanta, Georgia

Kazuo Mishima, M.D., Ph.D.
Director, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan

Katherine Marshall Moore, M.D.
Consultant, Department of Psychiatry and Psychology, Director, Mayo Clinic Anxiety Disorders Clinic, Mayo Clinic, Rochester, Minnesota

David J. Muzina, M.D.
Director, Center for Mood Disorders Treatment and Research, Associate Professor of Medicine, Cleveland Clinic Neurological Institute, Cleveland, Ohio

Henry A. Nasrallah, M.D.
Professor of Psychiatry and Neuroscience, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio

J. Craig Nelson, M.D.
Professor of Psychiatry, Leon J. Epstein, M.D., Chair in Geriatric Psychiatry, Director of Geriatric Psychiatry, University of California–San Francisco

Charles B. Nemeroff, M.D., Ph.D.
Reunette W. Harris Professor, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia

Alexander Neumeister, M.D.
Associate Professor of Psychiatry and Director of the Molecular Imaging Program of the Clinical Neurosciences Division, Yale University School of Medicine, West Haven, Connecticut

John W. Newcomer, M.D.
Gregory B. Couch Professor of Psychiatry, Psychology and Medicine and Medical Director, Center for Clinical Studies, Washington University School of Medicine, St. Louis, Missouri

D. Jeffrey Newport, M.D.
Associate Professor, Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia

Linda Nicholas, M.D.
Professor of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Seiji Nishino, M.D., Ph.D.
Professor of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California; Director, Sleep and Circadian Neurobiology Laboratory, Stanford Sleep Research Center, Palo Alto, California

Sandhaya Norris, M.D.
Physician, Mood Disorders Research Unit, University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada

Charles P. O'Brien, M.D., Ph.D.
Kenneth Appel Professor, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania

Giuseppe Pagnoni, Ph.D.
Dip. Scienze Biomediche, Sezione Fisiologia, Università di Modena e Reggio Emilia, Modeno, Italy

Daniel S. Pine, M.D.
Chief of Developmental Studies, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland

Steven R. Pliszka, M.D.
Professor and Vice Chair, Chief, Division of Child and Adolescent Psychiatry, Department of Psychiatry, The University of Texas Health Science Center at San Antonio

Bruce G. Pollock, M.D., Ph.D.
Professor and Head, Division of Geriatric Psychiatry, University of Toronto Faculty of Medicine; Sandra A. Rotman Chair in Neuropsychiatry, Rotman Research Institute, Baycrest; Vice President of Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

Robert M. Post, M.D.
Clinical Professor of Psychiatry, George Washington University, Washington, DC, and Penn State College of Medicine, Hershey, Pennsylvania; Head, Bipolar Collaborative Network, Bethesda, Maryland

David C. Purselle, M.D., M.S.
Assistant Professor, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine; Director of Acute Mental Health Services, Veterans Affairs Medical Center, Atlanta, Georgia

Charles L. Raison, M.D.
Assistant Professor, Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute (WCI), Emory School of Medicine, Atlanta, Georgia

B. Ashok Raj, M.D.
Physician Researcher, University of South Florida College of Medicine, Tampa, Florida

Mark Hyman Rapaport, M.D.
Chairman, Department of Psychiatry and Neurosciences, Cedars-Sinai Medical Center; Professor of Psychiatry and Biobehaviorial Sciences and Polier Family Endowed Chair for Schizophrenia and Related Disorders, David Geffen School of Medicine, University of California–Los Angeles

Mark M. Rasenick, Ph.D.
Professor of Physiology and Biophysics and Psychiatry, Departments of Physiology and Biophysics and Psychiatry, University of Illinois at Chicago, Chicago, Illinois

Martin Reite, M.D.
Diplomate, American Board of Sleep Medicine; Diplomate, American Board of Psychiatry and Neurology; Clinical Professor, Department of Psychiatry and Medical Director, Neuromagnetic Imaging Lab, University of Colorado School of Medicine, Denver, Colorado

Karl Rickels, M.D.
Stuart and Emily B.H. Mudd Professor of Behavior and Reproduction in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania

Laura Weiss Roberts, M.D., M.A.
Charles E. Kubly Professor and Chairman, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin

Donald S. Robinson, M.D.
Consultant, Worldwide Drug Development, Shelburne, Vermont

Steven P. Roose, M.D.
Professor of Clinical Psychiatry, College of Physicians and Surgeons, Columbia University; Co-Director, Neuropsychiatric Research Clinic, New York State Psychiatric Institute, New York, New York

Patrick H. Roseboom, Ph.D.
Associate Scientist in Psychiatry and Lecturer in Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin

Jerrold F. Rosenbaum, M.D.
Chief of Psychiatry, Massachusetts General Hospital; Stanley Cobb Professor of Psychiatry, Harvard Medical School, Boston, Massachusetts

J. Amiel Rosenkranz, Ph.D.
Assistant Professor, Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois

Carl Salzman, M.D.
Professor of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts

Alan F. Schatzberg, M.D.
Kenneth T. Norris Jr. Professor and Chair, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

S. Charles Schulz, M.D.
Professor and Head, Department of Psychiatry, University of Minnesota School of Medicine, Riverside, Minneapolis, Minnesota

Zafar A. Sharif, M.D.
Associate Clinical Professor of Psychiatry, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York

David V. Sheehan, M.D., M.B.A.
Distinguished University Health Professor, University of South Florida College of Medicine, Tampa, Florida

Daphne Simeon, M.D.
Associate Professor, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York

George M. Simpson, M.D.
Interim Chair and Professor of Research Psychiatry, Department of Psychiatry and the Behavioral Sciences, USC Keck School of Medicine, Los Angeles, California

Diane M. Sloan, Pharm.D.
Senior Medical Director, Advogent, Wayne, New Jersey

Joseph K. Stanilla, M.D.
Assistant Professor of Psychiatry, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania

Zachary N. Stowe, M.D.
Professor, Department of Psychiatry and Department of Gynecology/Obstetrics, Emory University School of Medicine, Atlanta, Georgia

Michael A. Strober, Ph.D.
Franklin Mint Chair in Eating Disorders and Professor of Psychiatry, Semel Institute for Neuroscience and Human Behavior and Stewart and Lynda Resnick Neuropsychiatric Hospital, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California

Steven T. Szabo, Ph.D.
Mood and Anxiety Disorders Program, Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland

Rajiv Tandon, M.D.
Chief of Psychiatry, State of Florida Program of Mental Health, Department of Children and Families, Tallahassee, Florida

Pierre N. Tariot, M.D.
Director, Memory Disorders Center, Banner Alzheimer's Institute; and Research Professor of Psychiatry, University of Arizona College of Medicine, Phoenix, Arizona

Michael E. Thase, M.D.
Professor, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania; and Adjunct Professor, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Gary D. Tollefson, M.D., Ph.D.
CEO/President, Orexigen Therapeutics, La Jolla, California

Karen Dineen Wagner, M.D., Ph.D.
Marie B. Gale Centennial Professor and Vice-Chair, Department of Psychiatry and Behavioral Sciences; Director, Division of Child and Adolescent Psychiatry, The University of Texas Medical Branch, Galveston, Texas

Po W. Wang, M.D.
Clinical Associate Professor, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California

Margaret B. Weigel, M.D.
Assistant Professor, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine; Staff Physician, Veterans Affairs Medical Center, Atlanta, Georgia

Anthony R. West, Ph.D.
Associate Professor, Department of Neuroscience, The Chicago Medical School of Rosalind Franklin University of Medicine and Science, North Chicago, Illinois

Christopher B. Wiegand, M.D.
Clinical Assistant Professor of Psychiatry, Department of Psychiatry, University of Arizona College of Medicine, Tucson, Arizona

Donna A. Wirshing, M.D.
Associate Professor, Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles; West Los Angeles Veterans Administration Medical Center, Los Angeles, California

Joanne D. Wojcik, P.M.H.C.N.S.–B.C.
Instructor in Psychiatry and Associate Director, Commonwealth Research Center and the Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts

Tsung-Ung W. Woo, M.D., Ph.D.
Assistant Professor of Psychiatry, Beth Israel Deaconess Medical Center and McLean Hospital, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts

Frank D. Yocca, Ph.D.
Vice President and Head, CNS and Pain Discovery, AstraZeneca Pharmaceuticals Co., Wilmington, Delaware

Kimberly A. Yonkers, M.D.
Associate Professor, Departments of Psychiatry, Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut

Elizabeth Ann Young, M.D.
Professor of Psychiatry, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan

Jiang-Zhou Yu, M.D., Ph.D.
Research Assistant Professor, Departments of Physiology and Biophysics and Psychiatry, University of Illinois at Chicago, Chicago, Illinois

Janos Zahajszky, M.D.
Medical Director of Outpatient Mental Health, California Pacific Medical Center, San Francisco, California

Wei Zhang, M.D., Ph.D.
Director, Anxiety and Traumatic Stress Program, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina

Charles F. Zorumski, M.D.
Samuel B. Guze Professor of Psychiatry, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri

Disclosure of Interests

The following contributors to this textbook have indicated a financial interest in or other affiliation with a commercial supporter, manufacturer of a commercial product, and/or provider of a commercial service as listed below:

Elias Aboujaoude, M.D. Research Support: Eli Lilly and Forest Laboratories (as co-investigator in clinical trials).
Matthew J. Bair, M.D., M.S. Advisory Board: Abbott, and Ortho-McNeil-PriCare Division.
Christos A. Ballas, M.D. Speakers Bureau: AstraZeneca, Cephalon, and Pfizer; Consultant: AstraZeneca, GlaxoSmithKline, Pfizer, and Wyeth.
Pierre Blier, M.D., Ph.D. Grant/Grant/Research Support: Eli Lilly, Forest Laboratories, Lundbeck, Sepracor, and Wyeth-Ayerst; Consultant/Advisory Board: Eli Lilly, Forest Laboratories, Lundbeck, Sepracor, and Wyeth-Ayerst; Speakers Bureau: Eli Lilly, Forest Laboratories, Lundbeck, Sepracor, and Wyeth-Ayerst.
Elisabeth B. Binder, M.D., Ph.D. Grant/Research Support: Doris Duke Foundation, GlaxoSmithKline, NARSAD, National Institutes of Health, and Pfizer; Speaker's Honorarium: AstraZeneca.
Charles L. Bowden, M.D. Grant/Research Support: Abbott Laboratories, Bristol-Myers Squibb, Elan Pharmaceuticals, GlaxoSmithKline, Janssen, Lilly Research, National Institute of Mental Health, Parke Davis, R.W. Johnson Pharmaceutical Institute, SmithKlineBeecham, and Stanley Medical Research Foundation, Consultant: Abbott Laboratories, GlaxoSmithKline, Janssen, Lilly Research, Sanofi-Synthelabo, and UCB Pharma; Speakers Bureau: Abbott Laboratories, AstraZeneca, GlaxoSmithKline, Janssen, Lilly Research, and Pfizer.
Peter F. Buckley, M.D. Grant/Research Support: AstraZeneca, National Institute of Mental Health, Janssen Pharmaceutica, Pfizer, Solvay, and Wyeth; Consultant (Honorarium/Expenses): Janssen Pharmaceutica and National Institute of Mental Health.
Joseph R. Calabrese, M.D. Grant/Research Support: Abbott, AstraZeneca, Cleveland Foundation, GlaxoSmithKline, Janssen, Lilly, NARSAD, Repligen, and Stanley Medical Research Institute; Federal Funding: Department of Defense, Health Resources Services Administration, and National Institute of Mental Health; Advisory Board: Abbott, AstraZeneca, Bristol-Myers Squibb, France Foundation, GlaxoSmithKline, Janssen, Johnson & Johnson Pharmaceutical Research & Development, and Solvay/Wyeth; CME Activities: AstraZeneca, Bristol-Myers Squibb, France Foundation, GlaxoSmithKline, Janssen, Johnson & Johnson, and Solvay/Wyeth.
Carla M. Canuso, M.D. Employed by: Ortho-McNeil Janssen Scientific Affairs; Stock: Johnson & Johnson.
Linda L. Carpenter, M.D. Grant/Research Support: NARSAD, National Institute of Mental Health, Pfizer, Sepracor, and UCB Pharma; Consultant/Advisory Board: Abbott, Bristol-Myers Squibb, Cyberonics, Medtronic, Novartis, Pfizer, Sepracor, and Wyeth; Honoraria for CME: APA, Cyberonics, and Wyeth; Speakers Bureau: AstraZeneca, Cyberonics, and Pfizer; Travel Support: Neuronetics.
Anita H. Clayton, M.D. Grant/Research Support: BioSame Pharmaceuticals, Boehringer-Ingelheim, Bristol-Myers Squibb, Eli Lilly, Forest Pharmaceuticals, GlaxoSmithKline, Neuronetics, Pfizer, Sanofi-Aventis, and Wyeth; Consultant/Advisory Board: Boehringer-Ingelheim, Bristol-Myers Squibb, Eli Lilly, Fabre-Kramer Pharmaceuticals, GlaxoSmithKline, Novartis Pharmaceuticals, Pfizer, Vela Pharmaceuticals, and Wyeth; Speakers Bureau/Honoraria: Eli Lilly, GlaxoSmithKline, Pfizer, and Wyeth.
Emil F. Coccaro, M.D. Consultant: Azevan Pharmaceuticals.
Kathryn M. Connor, M.D., M.H.S. Employed by: Merck & Co, Inc.
Joseph F. Cubells, M.D., Ph.D. Grant/Research Support: NARSAD, National Institute on Drug Abuse, National Institute of Mental Health, and The Robert W. Woodruff Fund of Emory University.
D.P. Devanand, M.D. Research Support: Eli Lilly, Forest Labs, and GlaxoSmithKline, and Wyeth.
C. Lindsay DeVane, Pharm.D. Grant/Research Support: National Institute on Drug Abuse and National Institute of Mental Health; Consultant: Bristol-Myers Squibb, CME, Eli Lilly, GlaxoSmithKline, Janssen Pharmaceuticals, Medscape, Novadel Pharma, Primedia Healthcare, and Theracos.
David F. Dinges, Ph.D. Grant/Research Support: Cephalon, and Merck; Consultant/Scientific Advisor: Arena Pharmaceuticals, Cephalon, GlaxoSmithKline, ILSI North America, Mars Masterfoods, Merck, Neurogen, Novartis, Pfizer, Procter & Gamble, and Takeda.
Barbara D'Orio, M.D., M.P.A. Grant/Research Support: American Foundation for Suicide Prevention, Emory Medical Care Foundation, and National Institute of Mental Health.
David L. Dunner, M.D. Grant/Research Support: Bristol-Myers Squibb, Cyberonics, Eli Lilly, Forest, GlaxoSmithKline, Janssen, Pfizer, and Wyeth; Consultant/Advisory Board: Bristol-Myers Squibb, Cypress, Corcept, Eli Lilly, Forest, GlaxoSmithKline, Janssen, Novartis, Otsuka, Pfizer, Roche Diagnostics, Shire, Somerset, and Wyeth; Speakers Bureau: Bristol-Myers Squibb, Eli Lilly, Forest, GlaxoSmithKline, Organon, Pfizer, and Wyeth.
Susana V. Fernandez, B.A. Research Support: National Institutes of Health.
Marlene P. Freeman, M.D. Research Support: Forest, Institute for Mental Health Research (Arizona), Lilly, National Institute of Mental Health, Pronova Biocare (research materials), Reliant (for investigator-initiated trials), and U.S. Food and Drug Administration.
Mark A. Frye, M.D. Research Support: Abbott Laboratories, Cephalon, GlaxoSmithKline, Janssen Pharmaceutica, and Pfizer; Consultant: Abbott Laboratories, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen Pharmaceutica, Organon, and Otsuka Pharmaceuticals; CME Supported Activities: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Organon, and Otsuka Pharmaceuticals; Travel Support: Bristol-Myers Squibb, Cephalon, Organon, and Otsuka Pharmaceuticals.
Keming Gao, M.D., Ph.D. Grant/Research Support: Abbott, AstraZeneca, GlaxoSmithKline, and NARSAD; Speakers Bureau: AstraZeneca.
Steven J. Garlow, M.D., Ph.D. Grant/Research Support: Janssen Pharmaceutical, NARSAD, and National Institute of Mental Health; Consultant: Eli Lilly, and Solvay Pharmaceuticals; Scientific Advisor/Grant Review: American Foundation for Suicide Prevention, Constella Group, and Oak Ridge Associated Universities; Honoraria: CME; Speakers Bureau: Eli Lilly, and Pfizer.
Alan J. Gelenberg, M.D. Research Support: Novartis Pharmaceuticals; Consultant: AstraZeneca, Best Practice, Cyberonics, Eli Lilly, Forest, GlaxoSmithKline, Novartis, Pfizer, and Wyeth; Stock Options: Vela Pharmaceuticals.
Charles F. Gillespie, M.D., Ph.D. Grant/Research Support: APIRE/Wyeth, National Institute on Drug Abuse, and NARSAD; Review Board: CME outfitters.
Donald C. Goff, M.D. Research Support: Bristol-Myers Squibb, Cephalon, Dainippon Sumitomo, Eli Lilly, Janssen Pharmaceuticals, Letters and Science, Organon, Pfizer, Primedia, Proteus, SG Cowen, Solvay/Wyeth, Vanda Pharmaceuticals, Verusmed, Vista Research, Xenoport, and Xytis.
Anthony A. Grace, Ph.D. Grant/Research Support: Lundbeck Pharmaceuticals; Consultant: Johnson & Johnson, and Taisho Pharmaceuticals.
Alan I. Green, M.D. Research Support: AstraZeneca, Bristol-Myers, Cyberonics, Forest, Janssen, Lilly, and Novartis; Consultant/Advisory Board: AstraZeneca, Cyberonics, Janssen, and Lilly; Stock: Johnson & Johnson, and Meylau.
Raquel E. Gur, M.D., Ph.D. Investigator: AstraZeneca.
Eric Hollander, M.D. Research Support: Abbott, FDA (Oprah products), National Institute on Drug Abuse, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, Ortho-McNeil, and Pfizer; Consultant: Abbott, and Neuropharm.
Florian Holsboer, M.D., Ph.D. Shareholder: Amectis Pharmaceuticals, Corcept, and Neurocrine.
Ned H. Kalin, M.D. Research Support/Consultant/Speakers Bureau: Amgen, AstraZeneca, Bristol-Myers Squibb, Corcept, CeNeRx Biopharma, Cypress Biosciences, Cyberonics, Forest Laboratories, GlaxoSmithKline, Janssen Pharmaceutica, Johnson & Johnson, Lilly, National Institute of Mental Health, Neurocrine Bio, Neuronetics, Pfizer Pharmaceuticals, Sanofi-Synthelabo, Stanley Foundation, and Wyeth-Ayerst; Editor: Nature and Psychoneuroendocrinology (Elsevier); Field Editor: Neuropsychopharmacology; Stock/Equity Holdings: Corcept, CeNeRx, and Neurocrine Biosciences; Owner: Promoter Neurosciences; Patents: U.S. Patent No. 7,071,323— Kalin NH, Landry CF, Nanda SA, Roseboom PH: Promoter sequences for corticotropin-releasing factor CRF2alpha and method of identifying agents that alter the activity of the promoter sequences; U.S. Patent No. 7,087,385—Kalin NH, Nanda SA, Roseboom PH: Promoter sequences for urocortin 2 and the use thereof; U.S. Patent No. 7,122,650—Kalin NH, Nanda SA, and Roseboom PH: Promoter sequences for corticotropin-releasing factor binding protein and use thereof; U.S. Patent Application No. 10/896544—Bakshi VP, Kalin NH, Nanda SA, Roseboom PH: Method of reducing CRF receptor mRNA.
Paul E. Keck Jr., M.D. Research Support: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Eli Lilly, Janssen Pharmaceutica, National Institute of Mental Health, National Institute on Drug Abuse, Pfizer, and UCB Pharma; Consultant: Bristol-Myers Squibb, Eli Lilly, Forest Laboratories, Organon, and Pfizer; Patents: U.S. Patent No. 6,387,956—Shapira NA, Goldsmith TD, Keck PE Jr. (University of Cincinnati): Methods of treating obsessive-compulsive spectrum disorder comprises the step of administering an effective amount of tramadol to an individual. Filed March 25, 1999; approved May 14, 2002.
David E. Kemp, M.D. Consultant: Abbott, Bristol-Myers Squibb, and Wyeth.
Terence A. Ketter, M.D. Grant/Research Support: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Eisai, Elan Pharmaceuticals, Eli Lilly, GlaxoSmithKline, Janssen Pharmaceutica Products, Novartis Pharmaceuticals Group, Repligen, Shire Pharmaceuticals, Solvay Pharmaceuticals, and Wyeth Pharmaceuticals; Consultant: Abbott Laboratories, AstraZeneca Pharmaceuticals, Bristol-Myers Squibb, Cephalon, Corcept Therapeutics, Elan Pharmaceuticals, Eli Lilly, Forest Laboratories, GlaxoSmithKline, Janssen Pharmaceutica Products, Jazz Pharmaceuticals, Merck, Novartis Pharmaceuticals, Pfizer, Repligen, Shire Pharmaceuticals Group, Solvay Pharmaceuticals, UCB Pharmaceuticals, and Wyeth Pharmaceuticals; Lecture Honoraria: Abbott Laboratories, AstraZeneca Pharmaceuticals, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen Pharmaceutica Products, Novartis Pharmaceuticals, Pfizer, and Shire Pharmaceuticals Group.
Clinton Kilts, Ph.D. Grant/Research Support: National Institutes of Health; Consultant/Advisory Board: Forest Laboratories, H. Lundbeck A/S, and Solvay Pharmaceuticals; Patents: U.S. Serial No. 6,375990 B1, Method and Devices for Transdermal Delivery of Lithium, Co-holder with C.B. Nemeroff, M.D., Ph.D.; Endowed Chair: Paul Janssen Endowed Chair of Neuropsychopharmacology, Emory University.
Lorrin M. Koran, M.D. Grant Support: Eli Lilly; Consultant: Jazz Pharmaceuticals.
K. Ranga R. Krishnan, M.D. Consultant: Amgen, Bristol-Myers Squibb, CeNeRx, Corcept, GlaxoSmithKline, Johnson & Johnson, Lundbeck, Merck, Organon, Pfizer, Sepracor, Somerset, and Wyeth.
Kurt Kroenke, M.D. Research Support: Eli Lilly, and Pfizer; Honoraria: Eli Lilly, and Forest.
David J. Kupfer, M.D. Consultant: Servier Amerique.
Allan I. Levey, M.D., Ph.D. Grant: Acadia Pharmaceuticals.
David A. Lewis, M.D. Research Support: Merck, and Pfizer; Consultant: BMS, Pfizer, Sepracor, and Wyeth.
Jeffrey A. Lieberman, M.D. Research Support: Acadia, Bristol-Myers Squibb, GlaxoSmithKline, Janssen, Merck, Organon, and Pfizer; Consultant: Eli Lilly, and Pfizer; Advisory Board: AstraZeneca, Eli Lilly, GlaxoSmithKline, Lundbeck, Organon, and Pfizer; Patent: Repligen.
David M. Lyons, Ph.D. Grant/Research Support: Public Health Service Grants DA16902, MH77884, and MH47573, Pritzker Neuropsychiatric Disorders Research Consortium which is supported by the Pritzker Neuropsychiatric Disorders Research Fund. A shared intellectual property agreement exists between the Pritzker Neuropsychiatric Disorders Research Fund and the University of Michigan, the University of California, and Stanford University to encourage the development of appropriate findings for research and clinical applications.
Husseini K. Manji, M.D. The work presented in Chapter 1 was undertaken under the auspices of the National Institute of Mental Health Intramural Program. Dr. Manji is now at Johnson & Johnson Pharmaceutical Research & Development.
Stephen R. Marder, M.D. Research Support: Allon, Epix, Merck, and Novartis; Consultant/Advisory Board: Abbott, Acadia, Bristol-Myers Squibb, GlaxoSmithKline, Lundbeck, Memory, Otsuka, Pfizer, and Wyeth.
Sanjay Mathew, M.D. Grant/Research Support: Alexza Pharmaceuticals, General Clinical Research Center at Mount Sinai School of Medicine, National Alliance for Research in Schizophrenia and Depression, National Institute of Mental Health Career Development Award K23MH0 69656, U19-MH-069056, and Novartis; Compensation: AstraZeneca, Jazz Pharmaceuticals, and Pfizer; Patent: Inventor on a use patent of ketamine for the treatment of depression. If ketamine were shown to be effective in the treatment of depression and received approval from the U.S. Food and Drug Administration (FDA) for this indication, Dr. Mathew could benefit financially.
Helen S. Mayberg, M.D. Consultant: Advanced Neuromodel Systems (ANS); Licensing of IP: ANS.
W. Vaughn McCall, M.D., M.S. Research Support: GlaxoSmithKline, MECTA, Mini Mitter, Neurocrine, Sanofi, Sepracor, Somaxon, and Wyeth; Speakers Bureau: GlaxoSmithKline, Sanofi, and Sepracor.
William M. McDonald, M.D. Grant/Research Support: Boehringer Ingelheim, Fuqua Foundation, Janssen, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, and NeuroNetics; Consultant: Bristol-Myers Squibb, Forest, Janssen, and NeuroNetics; Speakers Bureau: Bristol-Myers Squibb, Forest, Janssen, and Solvay.
Susan L. McElroy, M.D. Research Support: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Eisai, Eli Lilly, Forest Labs, GlaxoSmithKline, Janssen Pharmaceutica, Jazz Pharmaceuticals, National Institute of Mental Health, OREXIGEN Therapeutics, Ortho-McNeil Pharmaceutical, Pfizer, Sanofi-Synthelabo, Somaxon Pharmaceuticals, Stanley Medical Research Institute, and Takeda Pharmaceutical (serves as principal or co-investigator); Consultant/Advisory Board: Abbott Laboratories, AstraZeneca, Eli Lilly, GlaxoSmithKline, Janssen Pharmaceutica, Ortho-McNeil Pharmaceutical, and Wyeth-Ayerst; Patents: U.S. Patent No. 6,323,236B2, Use of Sulfamate Derivatives for Treating Impulse Control Disorders, and along with the patent's assignee, University of Cincinnati, Cincinnati, OH, receives payments from Johnson & Johnson Pharmaceutical Research & Development, L.L.C., which has exclusive rights under the patent.
Andrew H. Miller, M.D. Research Support: Centers for Disease Control and Prevention, GlaxoSmithKline, Janssen/Johnson & Johnson, National Institutes of Health, and Schering-Plough; Consultant/Advisory Board: Centocor, and Schering-Plough.
David J. Muzina, M.D. Grant/Research Support: Abbott Labs, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Novartis, Repligen, and Wyeth Pharmaceuticals; Speaking/Advisory Honoraria: AstraZeneca, GlaxoSmithKline, and Pfizer.
Henry A. Nasrallah, M.D. Grant/Research Support: AstraZeneca, GlaxoSmithKline, Janssen, Lilly, National Institute of Mental Health, Pfizer, and Sanofi-Aventis; Consultant: Abbott, AstraZeneca, Janssen, and Pfizer; Advisory Board: Abbott, AstraZeneca, Janssen, and Pfizer, Speakers Bureau: Abbott, AstraZeneca, Janssen, and Pfizer.
J. Craig Nelson, M.D. Advisory Board: Biovail, Bristol-Myers Squibb, Corcept, Eli Lilly, Forest, GlaxoSmithKline, Novartis, Orexigen, Organon, and Pfizer; Consultant: Bristol-Myers Squibb, Corcept, Forest, Merck, and Orexigen.
Charles B. Nemeroff, M.D., Ph.D. Research Support/Board of Directors/Equity Holdings: American Foundations for Suicide Prevention (AFSP), CeNeRx, Corcept, George West Mental Health Foundation, Mt. Cook, National Alliance for Research on Schizophrenia and Depression (NARSAD), National Institute of Mental Health, NovaDel Pharmaceuticals, and Reevax; Scientific Advisory Board: AstraZeneca, Forest Laboratories, Johnson & Johnson, NARSAD, PharmaNeuroboost, and Quintiles.
D. Jeffrey Newport, M.D., M.Div. Research Support: Eli Lilly, GlaxoSmithKline, Janssen, NARSAD, National Institutes of Health, and Wyeth; Speaker's Honoraria: AstraZeneca, Eli Lilly, GlaxoSmithKline, and Pfizer.
Linda Nicholas, M.D. Speakers Bureau: AstraZeneca.
Seiji Nishino, M.D., Ph.D. Research Support: Johnson & Johnson (The Effects of H3 Antagonists on Sleep in Narcoleptic Mice), Jazz Pharmaceuticals (A Retrospective Chart Study of the Pediatric Management of Narcolepsy, Narcolepsy in African Americans, and Narcolepsy in African American Patients-Hypocretin deficiency without cataplexy).
Charles P. O'Brien, M.D., Ph.D. Consultant/Advisory Board: Alkermes, Cephalon, Forest, and McNeil.
Steven R. Pliszka, M.D. Research Support: AstraZeneca, Eli Lilly, and McNeil Pediatrics; Consultant: Ortho-McNeil Scientific, and Shire; Speakers Bureau: McNeil Pediatrics, and Shire.
Bruce G. Pollock, M.D., Ph.D. Grant/Research Support: National Institutes of Health, and Janssen Pharmaceuticals; Advisory Board: Forest Laboratories; Consultant: Lundbeck, and Takeda; Speakers Bureau: Forest, and Lundbeck; Faculty: Lundbeck Institute.
Robert M. Post, M.D. Consultant/Speakers Bureau: Abbott, AstraZeneca, BMS, and GlaxoSmithKline.
David C. Purselle, M.D., M.S. Speakers Bureau: Pfizer; Faculty: Lilly.
Charles L. Raison, M.D. Consultant/Advisory Board: Centocor, Lilly, Schering, and Wyeth; Speakers Bureau: Lilly, and Wyeth.
Mark Hyman Rapaport, M.D. Grant/Research Support: Abbott Laboratories, AstraZeneca*, Corcept Therapeutics, Cyberonics, Forest Labs, GlaxoSmithKline, Janssen Pharmaceutica, NARSAD, NCCAM*, National Institute of Mental Health*, Novartis, Pfizer, Pharmacia Upjohn, Sanofi-Synthelabo, Solvay*, Stanley Foundation, UCB Pharma, VA Merit Award, Volkswagon Stiefhund, and Wyeth; Consultant: Brain Cells, Cyberonics*, Forest Labs, GlaxoSmithKline, Janssen Pharmaceutica*, NCCR*, Neurocrine Biosciences, Lilly, National Institute of Mental Health*, National Institute on Drug Abuse, Novartis, Pfizer*, Roche, Sanofi Synthelabo, Schwarz Pharmaceuticals, Solvay*, Sumitomo, and Wyeth*; Speakers Bureau: Cyberonics, Forest Labs*, GlaxoSmithKline, Janssen, Lilly, Novartis, Pfizer, Pharmaceutica, and Wyeth*. *Funding in the past 12 months.
Karl Rickels, M.D. Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, Forest Laboratories, Cephalon, Epix Pharmaceuticals, Genaissance Pharmaceuticals, Kramer-Fabre, Merck, National Institute of Mental Health, Pamlab, Pfizer, Somerset Pharmaceuticals, and Wyeth Lab; Honoraria/Consultant/Advisory Board: Cephalon, DOV Pharmaceuticals, Eli Lilly, Medicinova, Novartis Pharmaceuticals, Pfizer, PreDix Pharmaceuticals, and Sanofi-Synthelabo Research.
Donald S. Robinson, M.D. Employed by: Worldwide Drug Development.
Patrick H. Roseboom, Ph.D. Co-Owner: Promoter Neurosciences; Patents: U.S. Patent No. 7,071,323—Kalin NH, Landry CF, Nanda SA, Roseboom PH: Promoter sequences for corticotropin-releasing factor CRF2alpha and method of identifying agents that alter the activity of the promoter sequences; U.S. Patent No. 7,087,385—Kalin NH, Nanda SA, Roseboom PH: Promoter sequences for urocortin 2 and the use thereof; U.S. Patent No. 7,122,650—Kalin NH, Nanda SA, and Roseboom PH: Promoter sequences for corticotropin-releasing factor binding protein and use thereof; U.S. Patent Application No. 10/896544—Bakshi VP, Kalin NH, Nanda SA, Roseboom PH: Method of reducing CRF receptor mRNA.
Jerrold F. Rosenbaum, M.D. Consultant: Neuronetics, Organon, Somaxon Pharm, and Supernus; Advisory Board: Forest, Lilly, MedAvante, Novartis Pharm, Sanofi Pharm, and Wyeth Pharm; Speakers Bureau: Boehringer Ingelheim Italia, and Primedia Health Care (Educational Content Development); Equity Holdings: Compellis, MedAvante, and Somaxon.
Alan F. Schatzberg, M.D. Consultant: Abbott, BrainCells, CeNeRx, Corcept (co-founder), Eli Lilly, Forest Labs, Merck, Neuronetics, Novartis, Pathways Diagnostics, PharmaNeuroBoost, Quintiles, Synosis, and Wyeth; Speakers Bureau: GlaxoSmithKline; Equity Holdings: Corcept, Forest, Merck, Neurocrine, and Pfizer; Patents: Named inventor on pharmacogenetic use patents on prediction of antidepressant response.
S. Charles Schulz, M.D. Grant/Research Support: Abbott, AstraZeneca, Eli Lilly, and MIND Institute; Consultant: AstraZeneca, Eli Lilly, and Vanda; Honoraria: AstraZeneca, and Eli Lilly; Speakers Bureau: AstraZeneca, BMS, and Eli Lilly.
Zafar A. Sharif, M.D. Advisory Board: Bristol-Myers Squibb, and Janssen Pharmaceutica; Speakers Bureau: Bristol-Myers Squibb, and Janssen Pharmaceutica.
David V. Sheehan, M.D., M.B.A. Grant/Research Support: Abbott Laboratories, Andote Foundation, AstraZeneca, Avera Pharmaceuticals, Bristol-Myers Squibb, Burroughs Wellcome, Eisai, Eli Lilly, Forest Laboratories, GlaxoSmithKline, GlaxoWellcome, International Clinical Research (ICR), Janssen Pharmaceutica, Jazz Pharmaceuticals, Kali-Duphar, Mead Johnson, MediciNova, Merck Sharp & Dohme, National Institute on Drug Abuse, National Institutes of Health, Novartis Pharmaceuticals Corp., Parke-Davis, Pfizer, Quintiles, Sandoz Pharmaceuticals, Sanofi-Aventis, Sanofi-Synthelabo Recherche, SmithKlineBeecham, TAP Pharmaceuticals, United Bioscience, The Upjohn Company, Warner Chilcott, Wyeth-Ayerst, and Zeneca Pharmaceuticals; Consultant: Abbott Laboratories, Alexa, Alza Pharmaceuticals, Applied Health Outcomes/XCENDA, AstraZeneca, Avera Pharmaceuticals, Bristol-Myers Squibb, Cephalon, Cortex Pharmaceutical, Cypress Bioscience, Eisai, Eli Lilly, Forest Laboratories, GlaxoSmithKline, INC Research, Janssen Pharmaceutica, Jazz Pharmaceuticals, Labopharm, Layton Bioscience, Lilly Research Laboratories, Lundbeck, Denmark, MediciNova, National Anxiety Awareness Program, National Anxiety Foundation, National Depressive & Manic Depressive Association, Organon, Orion Pharma, Parexel lnternational Corporation, Pfizer, Pharmacia, Pharmacia & Upjohn, Pierre Fabre, France, Roche, Sanofi-Aventis, Sanofi-Synthelabo Recherche, Sepracor, Shire Laboratories, Inc., SmithKlineBeecham, Solvay Pharmaceuticals, Takeda Pharmaceuticals, Targacept, The Upjohn Company, Tikvah Therapeutics, Titan Pharmaceuticals, Wyeth-Ayerst, and ZARS; Speakers Bureau: Abbott Laboratories, AstraZeneca, Boehringer Ingelheim, Boots Pharmaceuticals, Bristol-Myers Squibb, Burroughs Wellcome, Charter Hospitals, Ciba Geigy, Dista Products Company, Eli Lilly, Excerpta Medica Asia, Glaxo Pharmaceuticals, GlaxoSmithKline, Hospital Corporation of America, Humana, ICI, Janssen Pharmaceutica, Kali-Duphar, Marion Merrill Dow, McNeil Pharmaceuticals, Mead Johnson, Merck Sharp & Dohme, Novo Nordisk, Organon, Parke-Davis, Pfizer, Pharmacia & Upjohn, Rhone Laboratories, Rhone-Poulenc Rorer Pharmaceuticals, Roerig, Sandoz Pharmaceuticals, Sanofi-Aventis, Schering Corporation, SmithKlineBeecham, Solvay Pharmaceuticals, TAP Pharmaceuticals, The Upjohn Company, Warner Chilcott, and Wyeth-Ayerst; Stock: Medical Outcome Systems.
George M. Simpson, M.D. Grant Support: AstraZeneca, Janssen, and Pfizer; Consultant: Janssen, Merck, and Pfizer.
Diane M. Sloan, Pharm.D. Employed by: Advogent (a medical communications agency that does work with Wyeth Pharmaceuticals).
Zachary N. Stowe, M.D. Grant/Research Support: GlaxoSmithKline, National Institutes of Health, and Wyeth; Advisory Board: BMS, GlaxoSmithKline, and Wyeth; Speaker's Honoraria: Eli Lilly, GlaxoSmithKline, Pfizer, and Wyeth.
Pierre N. Tariot, M.D. Grant/Research Support: Abbott Laboratories, AstraZeneca, Alzheimer's Association, Arizona Department of Health Services, Bristol-Myers Squibb, Eisai, Elan, Eli Lilly, Forest Laboratories, GlaxoSmithKline, Institute for Mental Health Research, Janssen Pharmaceutica, Merck, Mitsubishi Pharma Corporation, Myriad Pharmaceuticals, NIA, National Institute of Mental Health, Neurochem, Ono Pharmaceuticals, Pfizer, Sanofi-Synthelabo, Schwabe, Takeda Pharmaceuticals North America, and Wyeth Laboratories; Consultant: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Eisai, Eli Lilly, Forest Laboratories, GlaxoSmithKline, Janssen Pharmaceutica, Memory Pharmaceuticals, Merck, Myriad Pharmaceuticals, Novartis AG, Pfizer, Sanofi-Synthelabo, Schwabe, and Takeda Pharmaceuticals North America; Speakers Bureau: AstraZeneca, Eisai, Forest Pharmaceuticals, and Pfizer; Educational Fees: AstraZeneca, Eisai, Forest Laboratories, Lundbeck, and Pfizer; Patents: Biomarkers of Alzheimer's Disease.
Michael E. Thase, M.D. Consultant/Advisory Board: AstraZeneca, Bristol-Myers Squibb, Cephalon, Cyberonics, Eli Lilly, Forest Pharmaceuticals, GlaxoSmithKline, Janssen Pharmaceutica, MedAvante, Neuronetics, Novartis, Organon, Sepracor, Shire, Supernus Pharmaceuticals, and Wyeth-Ayerst Laboratories; Speakers Bureau: AstraZeneca, Bristol-Myers Squibb, Cyberonics, Eli Lilly, GlaxoSmithKline, Organon, Sanofi Aventis, and Wyeth-Ayerst Laboratories; Royalty/Patent/Other Income: American Psychiatric Publishing, Guilford Publications, Herald House, and W.W. Norton; Equity Holdings: MedAvante; Expert Testimony: Jones Day and Phillips Lyttle, and Pepper Hamilton.
Gary D. Tollefson, M.D., Ph.D. Employed by: Orexigen Therapeutics.
Karen D. Wagner, M.D., Ph.D. Research Support: National Institute of Mental Health; Consultant/Advisory Board: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Forest Laboratories, Janssen, Novartis, Otsuka, Pfizer, Sanofi Aventis, and Solvay.
Margaret B. Weigel, M.D. Grant/Stipend Support: Novartis Pharmaceuticals, and Ono.
Donna A. Wirshing, M.D. Speakers Bureau: Bristol-Myers Squibb, and Pfizer.
Frank D. Yocca, Ph.D. Employed by: AstraZeneca Pharmaceuticals Co.
Kimberly A. Yonkers, M.D. Grant Support: Lilly, National Institute of Mental Health, Pfizer, and Wyeth.
Jiang-Zhou Yu, M.D., Ph.D. Grant Support: Bristol-Myers Squibb, and ONO Pharmaceuticals.

The following contributors stated that they had no competing interests during the year preceding manuscript submission:
W. Stewart Agras, M.D.; Jonathan M. Amiel, M.D.; Josephine Astrid Archer, B.Sc.; Gregory S. Berns, M.D., Ph.D.; David R. Block, M.D.; Catherine Bresee, M.S.; Frank W. Brown, M.D.; Mary F. Brunette, M.D.; Monica Kelly Cowles, M.D., M.S.; Charles A. Dackis, M.D.; Albert A. Davis, B.S.; Karon Dawkins, M.D.; Clifford J. Ehmke, M.D.; Dwight L. Evans, M.D.; Amir Garakani, M.D.; Elizabeth H. Gillespie, D.O.; Robert N. Golden, M.D.; Todd D. Gould, M.D.; Ebrahim Haroon, M.D.; Christine Heim, Ph.D.; Jinger G. Hoop, M.D., M.F.A.; Walter H. Kaye, M.D.; Ashley P. Kennedy, B.S.; Ania Korszun, Ph.D., M.D., M.R.C.Psych.; Helena C. Kraemer, Ph.D.; Erin E. Krebs, M.D., M.P.H.; Joseph B. Layde, M.D., J.D.; Thomas W. Meeks, M.D.; Darlene S. Melchitzky, M.S.; Emmanuel Mignot, M.D., Ph.D.; Kazuo Mishima, M.D., Ph.D.; Katherine Marshall Moore, M.D.; Alexander Neumeister, M.D.; Sandhaya Norris, M.D.; Giuseppe Pagnoni, Ph.D.; Daniel S. Pine, M.D.; B. Ashok Raj, M.D.; Mark M. Rasenick, Ph.D.; Martin Reite, M.D.; Laura Weiss Roberts, M.D., M.A.; J. Amiel Rosenkranz, Ph.D.; Carl Salzman, M.D.; Daphne Simeon, M.D.; Joseph K. Stanilla, M.D.; Michael Strober, Ph.D.; Steven T. Szabo, Ph.D.; Rajiv Tandon, M.D.; Anthony R. West, Ph.D.; Po W. Wang, M.D.; Joanne D. Wojcik, P.M.H.C.N.S.–B.C.; Tsung-Ung W. Woo, M.D.; Janos Zahajszlay, M.D.; Charles F. Zorumski, M.D.